The comical underlining I feel has come from the personified stars and moon. Melies didn't just give these space forms action or life but actual personality. "signature image of a bullet-shaped rocket lodging itself in the eye of a smirking moon". Mark Pittillo, RottenTomato. I like how even though at that time we hadn't investigated outside of our world, Melies still put life into something that we were unsure about whether it had/was life or not. No one could tell him it didn't/did have life so he was free to make the 'smirking moon' have expressions and become amusing to audiences.
Throughout the film the mise en scene does contribute to the sci fi genre but it really goes up a notch when the scientists are exploring inside the moon. "as the travellers discover a world full of strange rock formations, waterfalls, and enormous mushrooms". Aycyas, 2008. He has created natural 'earth-boundees' and put them on foreign turf, then made them unnatural sizes. It seems as if Melies deliberately obscured his environments to make audiences of that time question if there is other life-forms out there? Whether they are bouncing beasts, massive mushrooms or worlds hidden inside a floating hollow rock.